Bioequivalence Study of Clopidogrel 75 Mg Tablets in Healthy Male Volunteers
نویسندگان
چکیده
منابع مشابه
Bioequivalence Study of Clopidogrel 75 Mg Tablets in Healthy Male Volunteers
Clopidogrel, a thienopyridine inhibitor of the platelet P2Y12 adenosine diphosphate (ADP) receptor, has been widely used for the prevention of stent thrombosis in patients with acute coronary syndrome [1]. To exert an antiplatelet effect, clopidogrel requires conversion to an active thiol metabolite (15% of total metabolites) via the cytochrome P450 pathway (especially CYP2C19*2) [1,2]. But the...
متن کاملBioequivalence Study of Donepezil Hydrochloride Tablets in Healthy Male Volunteers
The objective of this study was to investigate the bioequivalence of two formulations of 5 mg donepezil HCL tablets: Tonizep as the test and Aricept as the reference. The two products were administered as a single oral dose according to a randomized two-phase crossover with a 3-week washout period in 20 healthy Thai Male volunteers. After drug administration, serial blood samples were collected...
متن کاملBioequivalence study of 400 and 100 mg imatinib film-coated tablets in healthy volunteers.
The aim of the study was to investigate the bioavailability of a generic product of 100 mg and 400 mg imatinib film-coated tablets (test) as compared to that of a branded product (reference) at the same strength to determine bioequivalence. The secondary objective of the study was to evaluate tolerability of both products. An open-label, randomized, crossover, two-period, single-dose, comparati...
متن کاملBioequivalence study of 500 mg cefuroxime axetil film-coated tablets in healthy volunteers.
The aim of the study was to investigate the bioavailability of a generic product of 500 mg cefuroxime axetil film-coated tablets (test) as compared to that of a branded product (reference) at the same strength to determine bioequivalence and to apply for regulatory approval. The secondary objective of the study was to evaluate tolerability of both products. A double blinded, randomized, crossov...
متن کاملBioequivalence study of 30 mg pioglitazone tablets in Thai healthy volunteers.
OBJECTIVE To compare the bioequivalent parameters of 30 mg pioglitazone tablets manufactured locally (Glista) and originally (Actos). MATERIAL AND METHOD A randomized, single dose, two-treatment, two-period, two-sequence crossover study was conducted Twenty-four healthy volunteers were recruited at Siriraj Clinical Research Unit. Each subject received a 30 mg pioglitazone tablet of both formu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Bioequivalence & Bioavailability
سال: 2012
ISSN: 0975-0851
DOI: 10.4172/jbb.1000102